As a result of equivalent pharmacologic Attributes, it can be realistic to expect equivalent risk with concomitant use of opioid cough drugs and benzodiazepines, other CNS depressants, or Alcoholic beverages.
Get health care assist right away should you discover any of the subsequent: gradual/shallow respiration, intense drowsiness/issues waking up, confusion.
Promethazine is surely an H1 receptor blocking agent. In combination with its antihistaminic motion, it offers clinically valuable sedative and antiemetic results.
In case you are prescribed this medication on an everyday agenda and pass up a dose, consider it as soon as you remember. If it is near the time of the next dose, skip the skipped dose. Get your subsequent dose with the normal time. Do not double the dose to catch up.
Promethazine needs to be utilized with warning in people with bone marrow depression. Leukopenia and agranulocytosis are claimed, normally when promethazine HCl has become Utilized in Affiliation with other known marrow-harmful brokers.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers lower than 6 yrs of age. Concomitant administration of promethazine merchandise with other respiratory depressants has an Affiliation with respiratory despair, and at times Demise, in pediatric patients. The Affiliation does indirectly relate to individualized weight-based mostly dosing, which might if not permit Risk-free administration.
Browse the Medication Information furnished by your pharmacist Before you begin getting promethazine/phenylephrine/codeine and each time you obtain a refill. For those who have any inquiries, check with your medical professional or pharmacist.
Codeine In an embryofetal growth analyze in Expecting rats dosed through the period of organogenesis, codeine amplified resorptions and lowered fetal weights at a dose about 25 instances the MRHD (with a mg/m2 basis using a maternal oral dose of 120 mg/kg/working day); having said that, these effects occurred in the existence of maternal toxicity.
Hemodialysis will not be routinely utilised to boost the elimination of codeine or promethazine from the human body.
To offer you probably the most suitable and valuable info, and realize which information and facts is helpful, we could Mix your e mail and Web-site usage details with other info We've got about you. Should you be a Mayo Clinic client, this could involve secured well being facts.
This medication may perhaps contain sugar and/or Liquor. Caution is recommended Should you have diabetes, Alcoholic beverages dependence, or liver sickness. Request your medical professional or pharmacist about employing this merchandise properly.
Having said that, this influence is not constant and may be offset by an elevated rate of cervical dilation, which tends to shorten labor. Watch neonates exposed to opioids during labor for signs of excessive sedation and respiratory melancholy.
When utilized for an prolonged time, this medication may well not work as well and could involve different dosing. Speak with your medical professional if this medication stops Doing work properly.
Inform your doctor Should your cough isn't going to get well in five times. Also, convey to your medical professional if your ailment will get even worse, or When Promethazine codeine syrup you have a headache that doesn't disappear, fever, or rash. These could be symptoms of a serious healthcare challenge and should be checked by a health care provider.